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探讨鼻咽癌低氧放疗的临床应用价值。方法 :1993年 7月～ 1995年 10收治的 12 0例鼻咽癌患者 ,根据临床期别区组设计 ,随机分为低氧放疗组和常规放疗组 ,均给予钴 - 6 0外照射 ,面颈联合野照射 34Gy后改面颈分野照射至鼻咽中平面剂量 70Gy ,低氧放疗组病例在放疗同时吸入 10 .5 %的低氧。结果 :两组近期疗效、长期生成率无明显差异 (P >0 .0 5 ) ,而低氧放疗组严重口干反应、严重口腔粘膜反应明显低于常规放疗组 (P <0 .0 0 1) ;张口困难、放射性脑病的发生率低于常规放疗组 ,但无统计学意义 (P >0 .0 5 )。结论 :低氧放疗可减轻鼻咽癌患者放射治疗的副作用 ,降低并发症的发生率。低氧放疗能否降低鼻咽癌患者放射性脑病及严重张口困难等后遗症的发生率 ,尚难以推断。
To investigate the clinical value of hypoxic radiotherapy for nasopharyngeal carcinoma. Methods: A total of 120 patients with nasopharyngeal carcinoma admitted to our hospital from July 1993 to 1995 were randomly divided into hypoxia radiotherapy group and conventional radiotherapy group according to the design of clinical district block. Neck joint field irradiation 34Gy neck area after irradiation to the nasopharyngeal plane dose of 70Gy, hypoxia radiotherapy group radiotherapy while inhaling 10.5% of the hypoxia. Results: There was no significant difference in long-term efficacy between two groups (P> 0.05), but severe hypoxia radiation group had severe dry mouth reaction and severe oral mucosa reaction was significantly lower than that of conventional radiotherapy group (P <0.01) ); Mouth opening difficulties, the incidence of radiation encephalopathy is lower than the conventional radiotherapy group, but not statistically significant (P> 0.05). Conclusion: Hypoxic radiotherapy can reduce the side effects of radiotherapy in patients with nasopharyngeal carcinoma and reduce the incidence of complications. Hypoxic radiotherapy can reduce nasopharyngeal cancer patients with radiation encephalopathy and severe complications such as the incidence of sequelae, it is difficult to infer.