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用Haemoneti V_(50)血细胞分离机对22例活动性、难治性全身性红斑狼疮患者进行了103次去淋巴细胞-血浆疗法(LPE),每次平均清除1.12×10~9淋巴细胞,去血浆20～30ml/lg,1～3次开始显效。近期显效17例,有效3例,无效2例。随访12～54月,仍处于缓解14例,最长6例已48～54月。主要并发症是环磷酰胺引起的粒细胞减少症及感染。初步探讨了LPE对SLE免疫功能的影响。
Twenty-three patients with active, refractory systemic lupus erythematosus underwent 103 de-lymphocyte-plasma therapies (LPE) with the Haemoneti V 50 Hematocrit, with an average removal of 1.12 × 10 9 lymphocytes per visit Plasma 20 ~ 30ml / lg, 1 to 3 times markedly effective. The recent markedly effective in 17 cases, effective in 3 cases, 2 cases. Follow-up 12 to 54 months, still in remission in 14 cases, up to 6 cases have 48 to 54 months. The main complication is cyclophosphamide-induced neutropenia and infection. The effect of LPE on immune function of SLE was preliminarily discussed.