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1例69岁女性2型糖尿病患者因周围神经病给予α-硫辛酸注射液0.6 g入0.9%氯化钠注射液250 ml静脉滴注。停药18 h，患者于夜间突发冷汗，伴乏力、头晕和饥饿感。此后患者夜间反复出现发作性冷汗伴头晕、乏力，进食后可缓解，发作时末梢血糖为2.1 mmol/L。实验室检查示空腹血清胰岛素>6 945 pmol/L，胰岛素自身抗体阳性，胰岛素释放指数>29.00。诊断：自身免疫性低血糖症。考虑与α-硫辛酸注射液有关。给予醋酸泼尼松10 mg口服、3次/d，3 d后夜间低血糖症状减轻，5 d后症状消失。此后，将醋酸泼尼松逐渐减量至1.25 mg/d，约1年7个月后停用。此间，患者胰岛素自身抗体转阴，血清胰岛素恢复正常，未再发生低血糖症。“,”A 69-year-old female patient with type 2 diabetes mellitus received an IV infusion of alpha thioctic acid injection 0.6 g dissolved in 0.9% sodium chloride injection 250 ml for peripheral neuropathy. Eighteen hours after drug withdrawal, the patient had a sudden cold sweat with fatigue, dizziness, and hunger at night. After that, the patient repeatedly had paroxysmal cold sweat with dizziness and fatigue at night, which could be relieved after eating. The peripheral blood glucose at onset of symptoms was 2.1 mmol/L. Laboratory tests showed that fasting insulin was more than 6 945 pmol/L, insulin autoantibody was positive, and insulin release index was more than 29.00. The patient was diagnosed as having autoimmune hypoglycemia, which was considered to be related to alpha thioctic acid injection. Prednisone acetate 10 mg was given orally, thrice daily. Her symptoms of hypoglycemia were relieved 3 days later and disappeared 5 days later. Thereafter, prednisone acetate dose was gradually reduced to 1.25 mg/d and stopped about one year and 7 months later. During the treatment, her insulin autoantibody turned negative, serum insulin returned to normal, and hypoglycemia did not recur.