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目的:探讨不同方式不同厚度加组织等效膜(简称加膜)对乳腺癌术后胸壁电子线照射时的肺组织生物效应的特点。方法:通过以仿真人体组织等效模型所拟的典型成年女子左侧乳腺癌术后患者进行模拟照射,以6MeV电子线照射无膜、加0.5cm和1.0cm厚组织等效膜的仿真人体组织等效模型所拟的体表,用热释光剂量仪进行实际测量;通过动物实验,比较不同方式(全程和半程)加组织等效膜(0.5cm厚)对电子线胸壁照射时肺组织的生物效应特点。结果:在无膜及体表加盖0.5cm和1.0cm厚组织等效膜后,6MeV电子线照射时肺前缘的剂量降低,分别为63.7、30.7和13.4cGy。同时动物实验表明加膜组的肺组织病理炎症反应轻于不加膜组,半程加膜组肺的放射损伤与全程加膜组的肺放射损伤程度基本相同,而半程组的皮肤的放射性损伤轻于全程组。结论:加膜以后肺组织的放射损伤减少;采用半程加膜的胸壁照射方式,既可达到治疗的目的,又可减少肺组织的放射性损伤。
OBJECTIVE: To investigate the biological effects of different thickness and tissue-equivalent membranes on the lung tissue after the chest wall electron beam irradiation. Methods: The simulated adult human left breast cancer patients were simulated by simulated human tissue equivalent model. The simulated human tissues with 0.5cm and 1.0cm thick equivalent membranes were irradiated with 6MeV electron beam Equivalent model of the body surface, with a thermoluminescence dosimeter for the actual measurement; animal experiments, comparing different ways (full and half) plus tissue equivalent membrane (0.5cm thick) on the chest wall of electron beam irradiation lung tissue Biological effects of the characteristics. RESULTS: After the 0.5cm and 1.0cm tissue equivalent membranes were capped without membrane and body surface, the doses of 6MeV electron beam were reduced when they were irradiated, which were 63.7, 30.7 and 13.4 cGy, respectively. At the same time, animal experiments showed that the pathological inflammatory reaction of lung tissue in the membrane-added group was lighter than that of the non-membrane-added group. The radiation damage of the lung in the semi-membrane-added group was basically the same as that in the whole membrane- Injury lighter than the whole group. Conclusion: The radiation injury of lung tissue is reduced after the membrane is added. The chest wall irradiation with halfway membrane addition can not only achieve the purpose of treatment, but also reduce the radioactive damage of the lung tissue.