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目的:研究有机氯农药暴露与乳腺浸润性导管癌(IDC)发生的关系。方法:运用病例对照研究,留取患者血清标本5 ml和乳腺脂肪组织标本10 g,气相色谱仪检测血清和乳腺脂肪组织中有机氯农药暴露水平。结果:血清中β-六氯环己烷(β-HCH)和甲基五氯苯硫醚(PCTA)暴露在病例组和对照组之间差异有统计学意义(P<0.05),脂肪组织中β-HCH、PCTA和pp’-滴滴伊(pp’-DDE)暴露在病例组和对照组之间差异有统计学意义(P<0.05)。IDCⅠ、Ⅱ级和Ⅲ级之间差异有统计学意义(P<0.05)。血清中β-HCH暴露水平在IDCⅠ、Ⅱ级之间差异无统计学意义(P>0.05),在Ⅰ和Ⅲ级、Ⅱ和Ⅲ级之间差异有统计学意义(P<0.05);PCTA暴露水平在IDCⅠ和Ⅱ级、Ⅱ和Ⅲ级之间差异无统计学意义(P>0.05),Ⅰ和Ⅲ级之间差异有统计学意义(P<0.05)。脂肪组织中β-HCH、PCTA和pp’-DDE暴露水平在IDCⅠ和Ⅱ级、Ⅱ和Ⅲ级、Ⅰ和Ⅲ级之间差异均有统计学意义(P<0.05)。结论:有机氯农药暴露可能与IDC的发生有关,随着暴露水平的增加,IDC的恶性程度也随之增加。
Objective: To study the relationship between organochlorine pesticide exposure and the occurrence of breast invasive ductal carcinoma (IDC). Methods: Using case-control study, 5 ml serum samples from patients and 10 g breast adipose tissue samples were collected, and the levels of organochlorine pesticide exposure in serum and breast adipose tissue were detected by gas chromatography. Results: There were significant differences in the serum β-HCH and PCTA exposure between the case group and the control group (P <0.05). In the adipose tissue The differences of β-HCH, PCTA and pp’-DDE between the case group and the control group were statistically significant (P <0.05). There was significant difference between IDC Ⅰ, Ⅱ and Ⅲ (P <0.05). Serum levels of β-HCH were not significantly different between IDC Ⅰ and Ⅱ (P> 0.05), and there were significant differences between Ⅰ and Ⅲ, Ⅱ and Ⅲ (P <0.05) There was no significant difference in the level between IDCⅠ and Ⅱ, Ⅱ and Ⅲ (P> 0.05), and the difference between Ⅰ and Ⅲ was statistically significant (P <0.05). The levels of β-HCH, PCTA and pp’-DDE in adipose tissue were significantly different between IDCⅠ and Ⅱ, Ⅱ and Ⅲ, and Ⅰ and Ⅲ (P <0.05). Conclusion: The exposure of organochlorine pesticides may be related to the occurrence of IDC. As the level of exposure increases, the malignancy of IDC also increases.