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目的 测定子宫内膜癌患者血清层粘连蛋白 ( laminin,L N)水平及切除肿瘤对其影响。方法 用放射免疫法测定 14例子宫内膜癌、76例内膜正常的妇科良性疾病及 2例内膜增殖症患者血清 L N含量。结果 子宫内膜癌患者血清 L N明显高于内膜正常各良性疾病组 ( P<0 .0 5 )及子宫内膜增殖症组 ;手术切除肿瘤后 ,血清 L N水平显著下降 ( P<0 .0 5 ) ;术前血清 L N水平及术后 L N下降程度均有随内膜癌肌层浸润加深而上升趋势。结论 血清 L N水平与肿瘤的浸润过程可能密切相关 ;观察血清 L N水平及其变化对子宫内膜癌的诊断、病情及预后判断可能有一定参考价值
Objective To determine the level of serum laminin (L N) in patients with endometrial carcinoma and the effect of tumor excision. Methods Serum L N levels in 14 cases of endometrial cancer, 76 cases of normal endometrial benign diseases and 2 cases of intimal hyperplasia were determined by radioimmunoassay. Results Serum LN in patients with endometrial carcinoma was significantly higher than that in benign endometrial disease group (P <0.05) and endometrial hyperplasia group. After the tumor was removed, the serum LN level was significantly decreased (P <0. 0 5). The preoperative serum LN level and postoperative LN level decreased with the progression of intimal cancer invasion. Conclusions Serum LN level may be closely related to tumor invasion. It may be useful to observe the level of serum LN and its changes in the diagnosis, prognosis and prognosis of endometrial carcinoma