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目的了解镇江市男男性行为者(men who have sex with men,MSM)HIV、梅毒螺旋体血清抗体阳转和队列保持的情况及其影响因素。方法采用前瞻性队列研究,对符合纳入标准的调查对象进行间隔6个月的随访调查,收集社会人口学和行为学信息,并采集血样进行HIV和梅毒螺旋体血清抗体检测。结果共调查MSM456名,HIV和梅毒螺旋体血清抗体阳性率分别为7.7%(95%CI:5.40%～10.51%)和10.5%(95%CI:7.86%～13.71%)。基线建立HIV血清抗体阴性队列421人,6个月随访时队列保持率为27.1%(114/421),HIV和梅毒螺旋体血清抗体阳转率分别为8.24(95%CI:7.58～8.90)/100人年和12.64(95%CI:11.76～13.51)/100人年。比较失访组和在访组基线社会人口学及行为学特征,结果发现两组在婚姻状况、户籍所在地、文化程度、最近6个月寻找性伴场所和与商业性伴发生无保护的肛交等方面差异有统计学意义。结论镇江市MSM的HIV和梅毒螺旋体血清抗体阳转率处于较高水平,针对该人群进行有效的干预已迫在眉睫。
Objective To investigate the status of HIV seropositivity and cohort maintenance in men who have sex with men (MSM) and its influencing factors in Zhenjiang City. Methods A prospective cohort study was conducted. Follow-up surveys of 6-month follow-up were conducted to meet the inclusion criteria. Socio-demographic and behavioral information was collected and blood samples were collected for the detection of HIV and Treponema pallidum serological antibodies. Results A total of 456 MSM were detected. The positive rates of seropositivity for HIV and Treponema pallidum were 7.7% (95% CI: 5.40% -10.51%) and 10.5% (95% CI: 7.86% ~ 13.71%), respectively. A total of 421 HIV-negative cohorts were established at baseline, with a cohort retention rate of 27.1% (114/421) at 6 months of follow-up and seropositivity rates of HIV and TP seropositivity of 8.24 (95% CI: 7.58-9.90) / 100 Year and 12.64 (95% CI: 11.76 ~ 13.51) / 100 person-years. We compared the baseline demographic and behavioral characteristics of the lost group and the visiting group. The results showed that the two groups were divided into three groups based on their marital status, household registration, educational level, sexual partners in the last 6 months, and unprotected anal intercourse with commercial partners The differences were statistically significant. Conclusion The MSM seroconversion rate of HIV and Treponema pallidum in Zhenjiang City is at a high level, and effective intervention for this population is imminent.