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周期型马来丝虫皮下感染蒙古沙鼠主要的病理变化为淋巴管炎和淋巴结炎及其周围炎，在腰、髂、精索（卵巢）、肾和股淋巴尤为显著；淋巴管内含有成虫，病变为内皮细胞增生、淋巴栓塞，特别在精索周围的淋巴管．其周围可见以单核细胞为主的炎细胞浸润．局部淋巴结扩张，淋巴滤泡增生。肺部主要病变可见死的微丝蚴或幼虫或成虫，周围有许多嗜酸性白细胞，少数淋巴细胞、上皮样细胞、纤维母细胞和少数异物巨细胞形成肉芽肿性病变；1只雄鼠肺动脉内发现1条活成虫。开放期感染时可见脾中度肿大，红髓增生，许多组织细胞、大单核细胞、嗜酸性细胞及上皮细胞等浸润．实验结果证实沙鼠可用以研究人体淋巴丝虫病的病理变化。
Cyclophilus subtilis infection Mongolian gerbil main pathological changes for lymphangitis and lymphadenitis and its peripheral inflammation, especially in the lumbar, iliac, spermatic cord (ovary), kidney and femoral lymph; Lymphatic vessels containing adult, Lesions are endothelial cell proliferation, lymphatic embolism, especially in the spermatic cord around the lymphatic vessels. Around the monocyte-based inflammatory cell infiltration can be seen. Local lymph node expansion, lymphoid follicular hyperplasia. The main lesion of the lung can be seen dead microfilaria or larvae or adults, surrounded by many eosinophils, a small number of lymphocytes, epithelioid cells, fibroblasts and a few foreign body giant cells to form granulomatous lesions; one male rat pulmonary artery found 1 live adult. Open infection can be seen when the spleen moderate swelling, red pulp hyperplasia, many tissue cells, monocytes, eosinophils and epithelial cells and other infiltration. The experimental results confirmed that gerbils can be used to study the pathological changes of human lymphatic filariasis.