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1目的 探讨 P16蛋白在眼睑恶性肿瘤中的表达情况及其与眼睑恶性肿瘤发生、发展的关系。 2方法 应用免疫组化 SABC法检测 96例常见眼睑恶性肿瘤的 P16蛋白。 3结果 眼睑恶性肿瘤 P16蛋白阳性者均为细胞核染色。其中 2 8例基底细胞癌 (BCC) ,18例鳞状细胞癌 (SCC) ,13例睑板腺癌 P16蛋白呈阳性表达 ,阳性率分别为 70 .0 0 % ,5 4.5 5 % ,5 6 .5 2 % ,随肿瘤分化程度的降低 ,P16蛋白阳性表达率下降 ,高分化癌与低分化癌间差异有显著性 (P =0 .2 86 )。 4结论 P16蛋白的表达与眼睑恶性肿瘤的发生及分化程度有关。
1 Objective To investigate the expression of P16 protein in eyelid malignancies and its relationship with the occurrence and development of eyelid malignancies. 2 Methods Immunohistochemical SABC method 96 cases of common eyelid malignancy P16 protein. 3 results Eyelid malignancy P16 protein positive were nuclear staining. The positive rates of P16 protein in 28 cases of basal cell carcinoma (BCC), 18 cases of squamous cell carcinoma (SCC) and 13 cases of meibomian gland carcinoma were 70.0%, 4.55% and 56% respectively .5 2%. With the decrease of tumor differentiation, the positive rate of P16 protein decreased. There was significant difference between well differentiated carcinoma and poorly differentiated carcinoma (P = 0.286). 4 Conclusion P16 protein expression and eyelid malignancy and the occurrence of the degree of differentiation.