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目的 探讨TNF -α、内毒素在肝硬化上消化道出血中的作用及大黄防治机制。方法 45例乙型肝炎后肝硬化上消化道出血患者给予大黄治疗 ,治疗前后检测肝功、TNF -α、内毒素的变化 ,并与西咪替丁疗效对比。结果 经大黄治疗后 ,肝硬化上消化道出血时间明显缩短 ,肝功、TNF -α、内毒素水平明显下降。结论 TNF -α、内毒素是引起肝硬化上消化道出血原因之一 ,大黄有明显止血、改善肝功等作用 ,其作用机制可能与降低血清中TNF -α、内毒素的水平有关
Objective To investigate the role of TNF-α and endotoxin in cirrhosis and upper gastrointestinal bleeding and the mechanism of rhubarb prevention and treatment. Methods Forty-five patients with posthepatitic cirrhosis and upper gastrointestinal hemorrhage were given rhubarb treatment. The changes of liver function, TNF-α and endotoxin were detected before and after treatment. The curative effect was compared with that of cimetidine. Results After rhubarb treatment, cirrhosis of the upper gastrointestinal bleeding time was significantly shorter, liver function, TNF-α, endotoxin levels decreased significantly. Conclusions TNF-α and endotoxin are one of the causes of cirrhosis and upper gastrointestinal hemorrhage. Rhubarb has obvious hemostasis and hepatic function improvement, which may be related to the decrease of serum TNF-α and endotoxin levels