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为观察达英-35治疗多囊卵巢综合征(PCOS)在明显降低黄体生成素(LH)及睾酮(T)水平,改善患者内分泌状况的同时,是否改善其胰岛素抵抗(IR),35例PCOS患者服用复方醋酸环丙孕酮(达英-35)治疗3个周期,观察用药前后临床特征、血清激素水平、空腹血糖、空腹胰岛素(FIN)的变化。结果显示,治疗后34例PCOS患者月经恢复,多毛及痤疮评分下降(P<0.01),双侧卵巢体积明显缩小(P<0.01)。血清LH、FSH、T水平和LH/FSH明显下降(P<0.01)。FIN水平明显下降(P<0.01),IR也有相应降低(P<0.01),空腹血糖(FBG)和胰岛素敏感性指数(ISI)无明显改变(P>0.05)。达英-35有很强的抗雄作用,明显改善了PCOS患者的内分泌状况和临床症状。
To observe whether Da-Ying-35 treatment of polycystic ovary syndrome (PCOS) can significantly reduce the level of LH and testosterone (T), improve the endocrine status of patients and improve insulin resistance (IR). 35 PCOS The patients were treated with cyproterone acetate (Darlene-35) for 3 cycles and the changes of clinical features, serum hormone levels, fasting blood glucose and fasting insulin (FIN) before and after treatment were observed. The results showed that the recovery of menstruation, hirsutism and acne scores of 34 PCOS patients decreased (P <0.01) and the volume of both ovaries significantly decreased (P <0.01) after treatment. Serum LH, FSH, T levels and LH / FSH decreased significantly (P <0.01). FIN significantly decreased (P <0.01), IR decreased accordingly (P <0.01), while FBG and ISI showed no significant change (P> 0.05). Delta-35 has a strong anti-male effect, significantly improved the endocrine status of PCOS patients and clinical symptoms.