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目的:探讨窒息新生儿阴离子间隙(AG)变化及其与血清电解质的关系。方法:对335例出生时窒息并经复苏处理后的新生儿作血电解质、肾功能、动脉血气检测,计算AG值。结果:高AG 161例(48.06%),正常AG 162例(48.36%),低AG 12例(3.58%)。轻、重度窒息组高AG发生率分别为47.40%、52.17%;AG均值分别为(16.01±5.73)mmol/L、(17.31±6.86)mmol/L,其差异均无统计学意义。AG值与血清Na+成正比,与血清HCO3-成反比,与血清C l-无明显相关。结论:窒息新生儿高AG发生率高,AG值升高同血清Na+和HCO3-关系密切,应常规测定AG值以指导治疗,避免盲目补碱。
Objective: To investigate the changes of anion gap (AG) and its relationship with serum electrolytes in neonates with asphyxia. Methods: 335 cases of asphyxia at birth and after resuscitation for neonatal blood electrolytes, renal function, arterial blood gas detection, calculate the AG value. Results: There were 161 cases (48.06%) with high AG, 162 cases (48.36%) with normal AG and 12 cases (3.58%) with low AG. The incidences of high AG in mild and severe asphyxia groups were 47.40% and 52.17%, respectively. The mean AG values were (16.01 ± 5.73) mmol / L and (17.31 ± 6.86) mmol / L, respectively, with no significant difference. AG value is proportional to serum Na +, inversely proportional to serum HCO3-, and serum C l- no significant correlation. Conclusion: Asphyxia neonates with high incidence of high AG, AG increased with serum Na + and HCO3- closely related to the AG value should be routinely measured to guide treatment, to avoid blind alkali.