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目的探讨Livin在乳腺癌组织中的表达及与临床病理参数的关系。方法 2011年7月—2012年8月收集45例乳腺癌和40例正常乳腺组织标本,应用RT-PCR和免疫组化SP法检测45例乳腺癌及40例正常乳腺组织中Livin mRNA和蛋白表达情况,分析Livin表达与临床病理参数的关系。计数资料采用χ2检验,对Livin表达与临床病理参数间的关系采用Spearman分析,P<0.05为差异有统计学意义。结果 Livin mRNA和蛋白在乳腺癌组织中的阳性表达率分别为80.00%和75.56%,明显高于正常组织(7.69%),差异均有统计学意义(均P<0.05)。Livin在乳腺癌中的阳性表达与年龄、肿瘤大小、组织类型、临床分级及淋巴结转移无关(P>0.05)。结论 Livin在乳腺癌组织中表达上调,其过表达可能与乳腺癌的发生发展有关。
Objective To investigate the expression of Livin in breast cancer and its relationship with clinicopathological parameters. Methods 45 cases of breast cancer and 40 cases of normal breast tissues were collected from July 2011 to August 2012. The expressions of Livin mRNA and protein in 45 cases of breast cancer and 40 cases of normal breast tissues were detected by RT-PCR and immunohistochemical SP method The relationship between Livin expression and clinicopathological parameters was analyzed. Counting data using χ2 test, the relationship between Livin expression and clinicopathological parameters using Spearman analysis, P <0.05 for the difference was statistically significant. Results The positive rates of Livin mRNA and protein in breast cancer tissues were 80.00% and 75.56%, respectively, which were significantly higher than those in normal tissues (7.69%, both P <0.05). The positive expression of Livin in breast cancer was not related to age, tumor size, histological type, clinical grade and lymph node metastasis (P> 0.05). Conclusion The expression of Livin is up-regulated in breast cancer tissues, which may be related to the occurrence and development of breast cancer.