Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver

• 作 者: Natalia A Osna Dan Feng Murali
• 机 构: ResearchService,DepartmentofInternalMedicine,DepartmentofPathology,DepartmentofAnatomicPathology,Dep
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2016年38期
• 关键词: Methyl balance S-ADENOSYLMETHIONINE S-ADENOSYLHOMOCYSTEINE Guanidinoacetate ALCO
• 基金项目: Supported by a Merit Review grant BX001155(to Kharbanda KK)from the Department of Veterans Affairs,Office of Research and Development(Biomedical Laboratory Research and Development)

AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation def