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用免疫组织化学方法观察原癌基因蛋白 c- erb B2 在大鼠睾丸中的分布。结果 :未成年大鼠睾丸生精上皮细胞和间质细胞中均未见 c- erb B2 免疫染色阳性颗粒 ;成年大鼠睾丸曲细精管中的圆形精子细胞、精子和残体均可见 c-erb B2 蛋白存在。提示原癌基因 c- erb B2 的活性可能参与精子形成的调控。
Immunohistochemistry was used to observe the distribution of proto-oncogene c-erb B2 in rat testes. RESULTS: No positive c-erb B2 immunostaining particles were found in the seminiferous epithelium and mesenchyme of the testis of young rats. Round sperm cells, spermatozoa and debris in the testicular seminiferous tubules of adult rats showed c -erb B2 protein is present. Suggesting that the activity of proto-oncogene c-erb B2 may be involved in the regulation of spermatogenesis.