论文部分内容阅读
目的 探讨血小板内皮衍生因子 (PDGF)在乳腺癌中的表达及与肿瘤血管生成、转移和预后的关系。方法 采用免疫组织化学方法检测 6 0例乳腺癌组织中PDGF表达和微血管密度 (MVD)分布。结果 乳腺癌中PDGF表达阳性率为 6 5 0 % ,PDGF表达与组织学分级、临床分期、淋巴结转移、远处转移、早期死亡密切相关 (P <0 .0 5 ) ,与MVD有显著相关性 (P <0 .0 5 ) ,与肿瘤大小、ER、PR无关 (P >0 .0 5 )。结论 PDGF在乳腺癌血管生成中具有重要作用 ,PDGF阳性的乳腺癌易发生转移 ,预后不良
Objective To investigate the expression of platelet-derived endothelial growth factor (PDGF) in breast cancer and its relationship with tumor angiogenesis, metastasis and prognosis. Methods Immunohistochemistry was used to detect the distribution of PDGF and the distribution of microvessel density (MVD) in 60 cases of breast cancer. Results The positive rate of PDGF in breast cancer was 65.0%. The expression of PDGF was closely related to histological grade, clinical stage, lymph node metastasis, distant metastasis and early death (P <0.05), and had a significant correlation with MVD (P <0.05), but not tumor size, ER, PR (P> 0.05). Conclusion PDGF plays an important role in the angiogenesis of breast cancer. PDGF-positive breast cancer is prone to metastasis with poor prognosis