Base-mediated formal [3＋2] cycloaddition of β,γ-alkenyl esters and p-TsN3 for the synthesis of pyraz

• 作 者: Mi-Na Zhao Mei-Na Zhang Zhi-Hu
• 机 构: KeyLaboratoryofSyntheticandNaturalFunctionalMoleculeChemistryofMinistryofEducation
• 出 处: 科学通报：英文版
• 发表日期: 2017年7期
• 基金项目: AcknowledgmentsThis work was supported by the National Natural Science Foundation of China （21622203, 21472147, and 21272183） and Fund of Northwest University （334100035）.

A novel 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU)-mediated formal cycloaddition of β,γ-alkenyl esters with p-tolylsulfonylazide(p-TsN_3) for the synthesis of 3,5-disubstituted pyrazoles has been developed.The reaction proceeded through diazotization of β,γ-