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据估计1988年～1990年在印度比哈尔邦有10万黑热病人,按葡萄糖酸锑钠6ml/d6天疗法,30%的病人对此药无反应,如延长治疗时间至20天以上,虽可提高治愈率,但仍有约1/10病人无效。加之有的病人对戊脘脒亦无反应,且该药有一定毒性,价格昂贵,靠进口,故需有一个有效、安全、高敏感的治疗方案。选择对锑剂治疗(20mg/kg·d×20d)无效、脾穿刺原虫阳性、无严重继发感染的病人,共312例,随机分为3组。A组只用戊脘脒,按4mg/kg剂量静脉滴注,每周3次,直
It is estimated that from 1988 to 1990 in Bihar, India, there are 100,000 black patients, according to the antimony gluconate 6ml / d6 day therapy, 30% of the patients did not respond to this medicine, such as extending the treatment time to more than 20 days, although Can improve the cure rate, but still about 1/10 of patients invalid. In addition, some patients do not respond to pentamidine, and the drug has certain toxicity and is expensive. It needs an effective, safe and highly sensitive treatment plan. A total of 312 patients who were ineffective with antimony agent (20mg / kg · d × 20d), positive for Spleen protozoa without serious secondary infection, were randomly divided into three groups. Group A only pentamidine, 4mg / kg dose intravenous infusion, 3 times a week, straight