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1982年我们在积累了单次大剂量阿托品间歇反复使用取得抢救重度有机磷中毒成功经验的基础上,首先提出了一次剂量阿托品化抢救重度有机磷中毒的治疗方案。至1990年底,我们采用此方法共抢救中、重度有机磷农药中毒352例,取得了满意效果。在缩短阿托品化时间,减少并发症,降低病死率等方面有很多优点,现总结如下。临床资料一、一般情况 (一)性别与年龄男114例,女238例。年龄最小5岁,最大67岁,其中18～30岁占81%;(二)中毒原因服毒自杀者325例,其他27例;(三)毒物类别敌敌畏104例,乐果86例,敌百虫49例,1059中毒47例,1605中毒15例,灭杀毙18例,复合中毒(系指由两种以上有机磷农药)16例,其他17例;(四)服毒到就诊时间绝大多数病例(75%)于服毒后2小时内就诊。就诊时间愈晚,病死率愈高。见表1。
In 1982 we accumulated a single high-dose intermittent repeated use of atropine to obtain the successful experience of salvage severe organophosphate poisoning, based on the first proposed a dose of atropine treatment of severe organophosphorus poisoning treatment. By the end of 1990, we used this method to salvage 352 cases of moderate and severe organophosphorus pesticide poisoning and achieved satisfactory results. There are many advantages in shortening the time of atropine, reducing complications, reducing mortality, are summarized as follows. Clinical data First, the general situation (a) sex and age, male 114 cases, female 238 cases. The youngest 5 years old, the maximum age of 67, of which 18 to 30 years old accounted for 81%; (2) poisoning poisoning suicide in 325 cases, the other 27 cases; (c) poison categories of dichlorvos in 104 cases, 86 cases of dimethoate, trichlorfon 49 cases, 1059 poisoning in 47 cases, 1605 poisoning in 15 cases, killing and killing in 18 cases, compound poisoning (referring to two or more organophosphate pesticides) in 16 cases, the other 17 cases; (4) taking the drug to the vast majority of cases of treatment time (75%) visited within 2 hours after taking the drug. The later treatment time, the higher the case fatality rate. See Table 1.