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绿脓杆菌感染的难治性是众所周知的,但其急性感染和慢性感染的难治性的含义迥然有别。急性感染多发生于白血病、恶性肿瘤、胶原病、手术、烧伤、脏器移植等病人或新生儿,以肺炎或败血症的形式发病且迅速演变为重症感染,如延误治疗则很快转为重危,预后不良。然而,慢性感染多为继发性,如弥漫性全细支气管炎或囊性纤维化等疾病,常因菌群失调而合并绿脓杆菌慢性感染,尽管应用强有力的抗菌疗法,大部分
The refractory nature of Pseudomonas aeruginosa infection is well known, but its acute and chronic infections are quite different. Acute infections occur in patients with leukemia, malignant tumors, collagen diseases, surgery, burns, organ transplantation or newborns, pneumonia or sepsis and the rapid evolution of severe infections, such as delay treatment is quickly converted to critical , Poor prognosis. However, chronic infections are mostly secondary, such as diffuse panbronchiolitis or cystic fibrosis and other diseases, often due to flora and chronic infection with Pseudomonas aeruginosa, despite the use of potent antimicrobial therapy, the majority