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目的:调查湖州市女性人乳头瘤病毒(HPV)感染基因型的分子流行病学特点。方法:对450例湖州市女性宫颈分泌物应用基因芯片技术进行了18种高危型和5种低危型HPV型别检测,并结合年龄、文化程度等基本信息进行分析。结果:450例女性中共检出HPV阳性101例,占22.44%,其中单一感染80例,占17.78%;双重感染17例,占3.78%;三重及以上感染4例,占0.89%。101例阳性患者中有高危型HPV感染的为84例,占HPV总阳性人数的83.17%。阳性患者中高危型以16、33、58、18为主,低危型以6、11型为主。不同年龄组(≤30,31~40,41~50,>50)的HPV感染率分别为27.38%、21.32%、18.81%、15.56%,随年龄增长有下降趋势,但经统计学检验差异无显著性(P>0.05)。不同教育程度(小学及以下、初中、高中、大学及以上)的HPV感染率分别为23.08%、22.86%、21.74%、21.56%,也有随教育水平增高而下降的趋势,但经统计学检验差异无显著性(P>0.05)。结论:湖州市女性HPV感染并不少见,且高危型HPV感染所占比例较高,在不同年龄和文化水平中差异无显著性。对适当年龄段女性进行HPV感染筛查和及早治疗,对宫颈癌的防治有重要意义。
Objective: To investigate the molecular epidemiological characteristics of human papillomavirus (HPV) genotypes in Huzhou City. Methods: A total of 450 cases of cervical secretions from women in Huzhou City were genotyped by 18 kinds of high-risk and 5 kinds of low-risk HPV genotypes by using gene chip technology, and analyzed with basic information such as age and education level. Results: Of the 450 women, 101 were detected positive for HPV (22.44%), of which 80 were single infection (17.78%), 17 were double infection (3.78%), and 4 were infected by triple infection (0.89%). Of the 101 positive patients, 84 were high-risk HPV infections, accounting for 83.17% of the total HPV-positive patients. Positive patients in high-risk type to 16,33,58,18 mainly low-risk type 6,11-based. The infection rates of HPV in different age groups (≤30,31 ~ 40,41 ~ 50,> 50) were 27.38%, 21.32%, 18.81% and 15.56% respectively, with the decreasing trend with age, but the statistical difference was Significance (P> 0.05). The HPV infection rates of different education levels (elementary and junior high school, junior high school, high school, university and above) were 23.08%, 22.86%, 21.74% and 21.56% respectively. There was also a tendency of decreasing with the increase of education level. However, No significant (P> 0.05). Conclusion: HPV infection is not uncommon in Huzhou women, and the proportion of high-risk HPV infection is high. There is no significant difference in different age and cultural level. HPV infection screening and early treatment of women of the appropriate age have great significance for the prevention and treatment of cervical cancer.