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我院于2014年2月~2015年6月间收治的58例CM患者,随机分为对照组29例接受两性霉素B联合氟康唑诱导治疗,观察组29例患者接受伏立康唑联合两性霉素B共同治疗。结果对照组有效率为82.76%,观察组为96.55%,P<0.05。两组患者入院时、用药后一周、用药后2周患者脑脊液压力>330mm Hg例数、Pro、CI等指标结果,P>0.05。结论对于CM患者提供伏立康唑联合两性霉素B治疗,效果较好,但患者用药前后脑脊液压力、Pro、CI等指标无统计学意义。
58 patients with CM who were treated in our hospital from February 2014 to June 2015 were randomly divided into control group (n = 29) and amphotericin B combined with fluconazole (n = 29). In the observation group, 29 patients received voriconazole combined with amphotericin B co-treatment. Results The effective rate was 82.76% in the control group and 96.55% in the observation group, P <0.05. Two groups of patients on admission, one week after treatment, two weeks after treatment of patients with cerebrospinal fluid pressure> 330mm Hg number of cases, Pro, CI and other indicators results, P> 0.05. Conclusion Voriconazole combined with amphotericin B treatment in patients with CM, the effect is better, but patients before and after treatment of cerebrospinal fluid pressure, Pro, CI and other indicators was not statistically significant.