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目的探讨不同孕期妊娠对肌酐(Cr)、尿素氮(BUN)、肾小球滤过率(GFR)的影响。方法对246例早孕者、520例孕足月者及146例非妊娠者测定肾功能、血浆蛋白、身高、体重。通过MDRD7方程计算GFR。分析早孕组、孕足月组与对照组Cr、BUN及GFR差异。结果早孕组Cr明显低于孕足月组及对照组[(56±12)μmol/L VS(62±12)μmol/L、(64±12)μmol/L]。早孕组GFR显著高于孕足月组及对照组[(112±30)m l.m in-1.(1.73m2)-1VS(92±18)m l.m in-1.(1.73m2)-1、(90±20)m l.m in-1.(1.73m2)-1]。结论妊娠早期Cr、BUN等明显下降,肾小球滤过显著增加。孕足月时Cr、GFR恢复至非妊娠状态。GFR较Cr判断肾功能更敏感、更准确。
Objective To investigate the effects of pregnancy on creatinine (Cr), blood urea nitrogen (BUN) and glomerular filtration rate (GFR) during pregnancy. Methods 246 cases of early pregnancy, 520 cases of gestational term and 146 cases of non-pregnant women were measured renal function, plasma protein, height, weight. GFR was calculated by MDRD7 equation. The differences of Cr, BUN and GFR in early pregnancy group, full-term pregnancy group and control group were analyzed. Results Cr in the early pregnancy group was significantly lower than that in the premature pregnancy group and in the control group [(56 ± 12) μmol / L VS (62 ± 12) μmol / L, (64 ± 12) μmol / L) The GFR of early pregnancy group was significantly higher than that of gestational term group and control group [(112 ± 30) m lm in-1. (1.73m2) -1VS (92 ± 18) m lm in-1. 90 ± 20) m lm in-1. (1.73m2) -1]. Conclusion Early pregnancy Cr, BUN decreased significantly, glomerular filtration increased significantly. Pregnant full-term Cr, GFR returned to non-pregnant state. GFR is more sensitive than Cr to judge renal function, more accurate.