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目的 探讨胃食管反流病 (GERD)胃液体、固体排空情况及与pH值监测结果的相关性。方法 15例GERD患者分别进行胃镜检查、2 4h食管pH值监测和放射性核素胃排空功能测定 ,与对照组液体和固体胃排空率、胃半排空时间进行比较 ,分析GERD患者液体、固体排空率与食管炎及 2 4hpH值监测指标之间的关系。结果 GERD组液体胃排空率在 15、30min明显低于对照组 (P<0 0 5 ) ,固体胃排空率在各时间点均低于对照组 (P <0 0 5 )。GERD患者液体半排空时间与pH值监测总积分无相关性 (r=0 0 6 1,P >0 0 5 ) ;固体半排空时间与pH值监测总积分呈直线相关 (r=0 6 43,P <0 0 5 )。结论 GERD患者存在胃液体、固体排空延迟。固体半排空时间与pH值总积分呈直线相关。胃排空延迟可能是GERD发病机制的重要因素。
Objective To investigate the gastric emptying and gastric emptying in patients with gastroesophageal reflux disease (GERD) and its relationship with the results of pH monitoring. Methods Fifteen patients with GERD were examined by gastroscopy, pH value of the esophagus at 24 hours, and gastric emptying function of the radionuclide. Compared with the control group, the gastric emptying rate and the gastric emptying time of the liquid and the solid were compared. Relationship between solid emptying rate and esophagitis and monitoring of 24 hpH value. Results The gastric emptying rate in GERD group was significantly lower than that in control group at 15 and 30 minutes (P <0.05). The gastric emptying rate in GERD group was lower than that in control group at all time points (P <0.05). The half-emptying time of liquid in GERD patients had no correlation with the total value of pH monitoring (r = 0 0 6 1, P 0 05). The solid half-emptying time was linearly correlated with the total pH monitoring (r = 0 6 43, P <0 0 5). Conclusion Gastric fluid is present in GERD patients, and the emptying of the solid is delayed. The solid half-emptying time is linearly related to the total pH value. Delayed gastric emptying may be an important factor in the pathogenesis of GERD.