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Objective:To investigate the effect of epileptiform discharge on changes of sleep structure in patients with epilepsy. Methods:A total of 82 patients diagnosed with epilepsy were performed with polysomnography (PSG) concomitant with long-term video electroencephalogram (LTV EEG) to analyze their sleep structures and epileptic EEG. Results:The PSG in this study was marked by different levels of changes in sleep parameters with increased latency stage and decreased rapid eye movement (REM) sleep as well as increased times of arousals at night, in which 8 patients had no REM sleep. During sleep, epileptiform discharges had evidently inlfuence on phaseⅠ andⅢ~Ⅳ sleep of non-REM (NREM) and discharge group was more signiifcant in the increase of phaseⅠ sleep but decrease of phasesⅢ~Ⅳ sleep of NREM. Conclusion:Patients with epilepsy is often accompanied with disorders of sleep structures, especially those with epileptiform discharges during sleep. Application of PSG concomitant with LTV EEG are more beneifcial for the overall analysis of relationship between sleep structure and epileptiform discharges.