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目的:探讨胰岛素强化治疗初诊2型糖尿病的临床疗效以及对胰岛β细胞功能的影响。方法:选择在我院接受治疗的100例初诊2型糖尿病患者,采用计算机单盲分组法随机分为对照组和观察组各50例,对照组接受口服二甲双胍治疗,观察组接受胰岛素强化治疗,比较两组患者的血糖情况、胰岛素抵抗指数、胰岛β细胞功能指数、低血糖发生率。结果:治疗后观察组的空腹血糖、餐后2 h血糖、糖化血红蛋白均明显低于治疗前(P<0.05)和对照组治疗后(P<0.05);治疗后两组胰岛素抵抗指数均明显降低(P<0.05),胰岛β细胞功能指数明显增高(P<0.05),观察组较对照组胰岛素抵抗指数更低、胰岛β细胞功能指数更高(P<0.05);观察组低血糖发生率较对照组差异无统计学意义(P>0.05)。结论:针对初诊2型糖尿病患者采用胰岛素强化治疗,可有效降低患者的血糖水平,减轻其机体胰岛素抵抗,有利于修复胰岛β细胞功能,且安全可靠。
Objective: To investigate the clinical efficacy of intensive insulin treatment of newly diagnosed type 2 diabetes mellitus and its effect on pancreatic β-cell function. Methods: One hundred cases of newly diagnosed type 2 diabetic patients who were treated in our hospital were randomly divided into control group and observation group with 50 cases in each group. The control group received oral metformin, and the observation group received insulin intensive therapy. Two groups of patients with blood glucose, insulin resistance index, β-cell function index, the incidence of hypoglycemia. Results: After treatment, fasting blood glucose, postprandial 2-h blood glucose and HbA1c in the observation group were significantly lower than those before treatment (P <0.05) and those in the control group after treatment (P <0.05); insulin resistance index (P <0.05). The function index of pancreatic β-cell was significantly increased (P <0.05), the insulin resistance index of the observation group was lower and the function index of pancreatic β-cell was higher (P <0.05). The incidence of hypoglycemia in the observation group was significantly higher than that of the control group There was no significant difference in the control group (P> 0.05). CONCLUSIONS: Insulin-enhanced therapy for patients with newly diagnosed type 2 diabetes mellitus can effectively reduce the blood glucose level and reduce the body’s insulin resistance, which is beneficial for the repair of islet β-cell function and is safe and reliable.