论文部分内容阅读
目的了解上海市居民经小麦粉摄入的脱氧雪腐镰刀菌烯醇(DON)及其乙酰衍生物3-乙酰基-脱氧雪腐镰刀菌烯醇(3-Ac-DON)和15-乙酰基-脱氧雪腐镰刀菌烯醇(15-Ac-DON)的暴露总量。方法利用高效液相色谱-串联质谱法对2011~2013年上海市售小麦粉中DON、3-Ac-DON、15-Ac-DON的含量分别进行检测,计算三者的总量。并结合上海市居民小麦粉摄入数据,以该化合物组的暂定每日最大耐受摄入量(PMTDI)1μg/(kg BW·d)为参考,对上海市居民经小麦粉摄入的DON及其乙酰衍生物的暴露总量分别进行点评估和概率评估。结果 (1)点评估显示,对于受到DON及其乙酰衍生物不同水平污染(均数、P50、P75、P90和P95)的小麦粉,人群在小麦粉均数和P50摄入水平时,毒素暴露总量皆低于PMTDI(占其18%~83%),而在小麦粉P95摄入水平时,毒素暴露总量皆高于PMTDI(为其1.08~2.55倍)。(2)概率评估显示,总人群、小麦粉食用人群和<15岁人群通过小麦粉摄入的DON及其乙酰衍生物的暴露总量低于PMTDI概率分别为89.99%、87.00%和76.55%。结论随着小麦粉摄入量的增高,上海市居民的DON及其乙酰衍生物的暴露风险增高;多数人摄入小麦粉是安全的,但有10.01%的人群处于风险状态,其中<15岁人群是DON及其乙酰衍生物暴露的高危人群。
Objective To investigate the effects of deoxynivalenol (DON) and acetyl derivatives 3-acetyl-deoxynivalenol (DON) and 15-acetyl- Total exposure to deoxynivalenol (15-Ac-DON). Methods The contents of DON, 3-Ac-DON and 15-Ac-DON in commercial wheat flour from Shanghai in 2011-2013 were detected by high performance liquid chromatography-tandem mass spectrometry, respectively. Combined with the data of intake of wheat flour of Shanghai residents, taking the 1 mg / (kg BW · d) of the tentative daily maximum tolerable intake (PMTDI) of this compound group as reference, the DON and The total amount of acetyl derivative exposure were evaluated point and probability. Results (1) The point assessment showed that for wheat flour at different levels of contamination with DON and its acetyl derivatives (mean, P50, P75, P90 and P95), the total population of toxins Were lower than PMTDI (accounting for 18% ~ 83%). However, at the level of P95 intake of wheat flour, the total amount of toxin exposure was higher than PMTDI (1.08-2.55 times). (2) Probability assessment showed that the total exposure to DON and its acetyl derivatives by total population, wheat flour eaters and <15 years old population via wheat flour was 89.99%, 87.00% and 76.55% less than that of PMTDI, respectively. Conclusions With the increase of wheat flour intake, the residents of Shanghai have a higher risk of exposure to DON and its acetyl derivatives. Most people are safe to consume wheat flour but 10.01% of the population is at risk. Among them, the population aged <15 is DON and its acetyl derivatives exposure of high-risk groups.