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目的:研究蝙蝠葛酚性碱对实验性心肌缺血的保护作用。方法:结扎大鼠冠状动脉左前降支建立急性心肌缺血模型,监测标准Ⅱ导心电图;颈总动脉取血,测定血清超氧化物歧化酶(SOD)的活性,丙二醛(MDA)的含量,乳酸脱氢酶(LDH)及肌酸激酶(CK)的活性。结果:蝙蝠葛酚性碱可抑制ST段抬高幅度,增强超氧化物歧化酶(SOD)的活性,降低丙二醛(MDA)的含量和乳酸脱氢酶(LDH)、肌酸激酶(CK)的活性。结论 蝙蝠葛酚性碱对大鼠实验性心肌缺血具有保护作用,其机理可能与抗自由基生成,增强心肌耐缺血能力有关。
Objective: To study the protective effect of phenolic alkaloids from Menispermum dauricum on experimental myocardial ischemia. METHODS: The left anterior descending coronary artery was ligated to establish an acute myocardial ischemia model. The standard II lead electrocardiogram was monitored; blood was taken from the common carotid artery to determine the activity of serum superoxide dismutase (SOD) and the content of malondialdehyde (MDA). , lactate dehydrogenase (LDH) and creatine kinase (CK) activity. RESULTS: Phenolic alkaloids of D. batlia inhibited the amplitude of ST segment elevation, enhanced the activity of superoxide dismutase (SOD), decreased the content of malondialdehyde (MDA), and lactate dehydrogenase (LDH) and creatine kinase (CK). ) activity. Conclusion The phenolic alkaloids of D. batlia has a protective effect on experimental myocardial ischemia in rats, and its mechanism may be related to anti-free radical production and enhancement of myocardial ischemia tolerance.