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研究者在50年前提出“成体肝组织内存在肝干细胞”这一假说.肝干/祖细胞研究对干细胞基础研究及其临床治疗研究都有着重要的意义.研究者也已从损伤的人类和啮齿动物的肝组织中分离到激活的肝干/祖细胞,并建立了相应的培养体系.目前的研究表明,肝内存在多个具有干细胞特性的细胞,且它们位于肝内不同的区域.另外,潜在的肝干/祖细胞的分子表达谱也已得到一定的阐述.本文结合肝干/祖细胞的研究,对成体肝干/祖细胞的潜在类型、来源与定位作一回顾.
Researchers put forward the hypothesis of “presence of hepatic stem cells in adult liver tissue” 50 years ago.Hepatic stem / progenitor cell research is of great importance for the basic research of stem cells and its clinical treatment research.The researchers have also studied from the point of injury Human and rodent liver tissue was isolated from activated liver stem / progenitor cells, and established a corresponding culture system.Researches have shown that there are multiple cells with stem cell characteristics in the liver, and they are located in different regions of the liver In addition, the molecular expression profiles of potential hepatic stem / progenitor cells have also been expounded.In this paper, we review the potential types, origin and localization of adult liver stem / progenitor cells in combination with liver stem / progenitor cells.