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目的:观察充填法硬膜外阻滞对胎儿生长受限(FGR)患者妊娠结局的影响,以进一步探寻治疗FGR的新途径。方法:收集孕32~34周确诊为FGR病例,随机分为两组,治疗组采用连续充填法硬膜外阻滞(0.3%罗哌卡因混合液)治疗,导管保留7日;对照组给予常规治疗7日。分别于治疗前和治疗后1周行彩色超声检查,监测胎儿生长情况和脐血流变化,追踪记录胎儿妊娠结局、新生儿阿氏评分、体重、出生孕周、胎盘重量,同时记录患者的不良反应。结果:治疗组治疗后新生儿的体重及胎盘重量均明显大于对照组,差异有统计学意义(P<0.05)。两组新生儿窒息、早产、足月小样儿发生率和新生儿死亡发生率相比,差异无统计学意义(P>0.05),且不良反应轻微。结论:充填法硬膜外阻滞可以有效地改善子宫胎盘血流量,促进胎儿生长发育。
Objective: To observe the effect of filling epidural block on pregnancy outcome in patients with FGR, so as to further explore new ways to treat FGR. Methods: The cases with FGR diagnosed 32 to 34 weeks’ gestation were randomly divided into two groups. The treatment group was treated with continuous filling epidural block (0.3% ropivacaine mixture) and the catheter was reserved for 7 days. The control group was given Routine treatment on the 7th. Color ultrasound was performed before treatment and one week after treatment to monitor fetal growth and changes of umbilical blood flow. The fetus pregnancy outcome, neonatal Asperger’s score, body weight, gestational age and placental weight were recorded and recorded. reaction. Results: After treatment, the body weight and placental weight of newborns in the treatment group were significantly greater than those in the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of asphyxia, premature birth, full-term infant and neonatal death between the two groups (P> 0.05), and mild adverse reactions. Conclusion: Filling method of epidural block can effectively improve uterine placental blood flow and promote fetal growth and development.