促渗剂Azone对几种药物透皮速率的影响

• 作 者: 沈子龙 徐进宜 蔺胜照 郭素珍
• 机 构: 中国药科大学药理教研室,中国药科大学药理教研室,中国药科大学药理教研室,中国药科大学药理教研室 南京,南京,南京,南京
• 出 处: 中国药理学通报
• 发表日期: 1989年01期
• 关键词: 促渗剂 Azone 透皮吸收 细辛醚 透皮促渗剂 硝酸甘油 硝烟酯 α—细辛醚 放射性示踪剂 硝酸甘油贴剂

Azone(氮酮)是目前国内外所应用的最好的药物透皮吸收促渗剂之一。本文用~3H-Azone作示踪剂,以离体皮肤体外流通扩散室法,研究了国产Azone对α-细辛醚、硝烟酯和硝酸甘油贴剂中药物渗透速率的影响。实验结果表明,Azone能显著增加上述三种药物的渗透速率,在Azone含量为4.8％时,硝烟酯、硝酸甘油和α-细辛醚的渗透速率分别增加133.7％、82.1％和34.5％,而且增渗作用持久。

Azone (Azone) is one of the best transdermal absorption and penetration enhancers currently used at home and abroad. In this paper, ~ 3H-Azone as a tracer to ex vivo skin through the diffusion chamber method to study the domestic Azone α-asarone, nicotinate and nitroglycerin drug permeation rate of the impact. The experimental results showed that Azone significantly increased the penetration rate of the above three drugs, and the permeation rates of nicotinate, nitroglycerin and α-asarone were increased by 133.7%, 82.1% and 34.5% at Azone content of 4.8% Increased permeability effect lasting.