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[目的]探讨人乳头状瘤病毒(HPV)感染与宫颈病变的关系。[方法]对2010年1月至2012年12月就诊的2423例病例进行液基细胞学检查和HPV检测,对细胞学诊断≥ASCUS及HPV检测为高危阳性的病例进行阴道镜下宫颈组织活检。[结果]在2423例病例中,HPV阳性率为36.11%(875/2423)。在ASCUS、LSIL、HSIL、SCC中HPV阳性率分别为54.13%、71.67%、93.85%和100.00%。组织学诊断CINⅠ、CINⅡ、CINⅢ、SCC病变中HPV阳性率分别为76.74%、85.0%、90.91%和100.00%。HPV16的检出率在不同宫颈病变中均居首位,且随宫颈病变的级别升高而感染率升高。[结论]HPV16是最常见的高危型。HPV检测并联合液基细胞学和组织学检查能更有效地筛查宫颈病变,为预防宫颈癌提供可靠的科学依据。
[Objective] To investigate the relationship between human papillomavirus (HPV) infection and cervical lesions. [Methods] Liquid-based cytology and HPV testing were performed on 2423 cases treated from January 2010 to December 2012. Colposcopic biopsy of cervical tissue was performed on cases with high risk of cytological diagnosis of ≥ASCUS and HPV. [Results] Among 2423 cases, the positive rate of HPV was 36.11% (875/2423). The positive rates of HPV in ASCUS, LSIL, HSIL and SCC were 54.13%, 71.67%, 93.85% and 100.00%, respectively. Histological diagnosis of CIN Ⅰ, CIN Ⅱ, CIN Ⅲ, SCC lesions of HPV positive rates were 76.74%, 85.0%, 90.91% and 100.00%. The detection rate of HPV16 ranks first in different cervical lesions, and the infection rate increases with the level of cervical lesions. [Conclusion] HPV16 is the most common high-risk type. HPV testing combined with liquid-based cytology and histological examination can more effectively screen for cervical lesions for the prevention of cervical cancer provide a reliable scientific basis.