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对142名长期接触硝基氯苯作业工人连续3年体检资料分析结果表明:神衰症候群、上呼吸道粘膜刺激及消化系统症状和体征检出率、MHb定量等均高于对照组且与空气中浓度有关。均值为0.96mg/m3时,上述指标均高于对照组(P<0.01);均值为0.51mg/m3,空气浓度均未超过MAC时与对照组比较,以及接触组间比较,部分指标存在差异(P<0.05或P<0.01)。提出MHb定量可作为接触硝基氯苯的生物监测指标,建议进一步研究其生物接触限值。
Analysis of 142 consecutive workers exposed to nitrochlorobenzene for three consecutive years showed that the detection rate of the symptoms and signs of upper respiratory tract mucous membrane and upper respiratory tract mucosa, the MHb quantification, and others were all higher than those in the control group and in the air Concentration related. When the average value was 0.96mg / m3, the above indexes were higher than the control group (P <0.01); mean was 0.51mg / m3, when the air concentration did not exceed MAC, compared with the control group, Some indicators were different (P <0.05 or P <0.01). It is proposed that the quantitative determination of MHb can be used as biological monitoring indicator of exposure to nitrochlorobenzene, and it is suggested to further study its biological exposure limit.