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目的探讨细支气管肺泡癌(BAC)与伴有BAC性质的肺腺癌(ADWBF)即混合型肺腺癌中HIF-1α与P53表达差异及相关性。方法收集BAC和ADWBF患者的临床病理资料及石蜡标本并分为BAC组和ADWB组,对两组患者临床病理资料进行比较,采用SP免疫组化法检测HIF-1α与P53在两组中的表达情况,采用χ2检验分析两者在两组病例中的表达差异及相关性。结果 两组在性别构成和肿瘤大小存在差异(P<0.05),HIF-1α、P53阳性表达率分别为25.0%(8/32)和49.3%(34/69),6.3%(2/32)和26.1%(18/69),差异均有统计学意义(P<0.05),HIF-1α和P53表达具有明显的正相关性(P<0.05,rp=0.338)。结论 HIF-1α和P53在肺腺癌的发生和进展中起到重要作用,并且两者之间存在协同作用。
Objective To investigate the difference and correlation between HIF-1α and P53 expression in bronchial alveolar carcinoma (BAC) and lung adenocarcinoma (ADWBF) associated with BAC. Methods The clinical and pathological data and paraffin specimens from patients with BAC and ADWBF were collected and divided into BAC group and ADWB group. The clinicopathological data of two groups were compared. The expression of HIF-1α and P53 in both groups were detected by SP immunohistochemistry Cases, usingχ2 test analysis of the two groups in the difference between the two groups and the correlation. Results The positive rates of HIF-1α and P53 were 25.0% (8/32), 49.3% (34/69), 6.3% (2/32) respectively in the two groups (P <0.05) And 26.1% (18/69) respectively. The difference was statistically significant (P <0.05). There was a significant positive correlation between HIF-1α and P53 expression (P <0.05, rp = 0.338). Conclusions HIF-1α and P53 play an important role in the occurrence and progression of lung adenocarcinoma, and there is a synergistic effect between the two.