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目的:观察通窍定眩汤治疗痰瘀互结型眩晕高血压的疗效及分析作用机制。方法:选取我院2012年1月-2015年9月所收治痰瘀互结型眩晕高血压患者96例作为研究对象,按照随机数表法分为观察组与对照组,各48例。对照组采取单纯西药治疗,观察组在对照组基础上联合通窍定眩汤,比较两组治疗前后血压(SBP、DBP)、治疗总有效率、治疗前后胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)等血脂指标及治疗期间药物不良反应发生率。结果:观察组SBP与DBP达标率分别为91.7%、87.5%,高于对照组72.9%、68.8%(均P<0.05)。观察组治疗总有效率为89.6%,高于对照组64.6%(P<0.05)。两组治疗前TC、TG、LDL-C无显著差异(P>0.05);治疗后观察组TC、TG、LDL-C高于治疗前及对照组治疗后(均P<0.05)。结论:通窍定眩汤治疗痰瘀互结型眩晕高血压可强化西药的控压效果并改善血脂,更有效缓解眩晕症状,安全性高,效果理想。
Objective: To observe the effect of Tongqiao decoction on the treatment of phlegm and blood stasis type vertigo and its mechanism of action. Methods: A total of 96 patients with phlegm and blood stasis type vertigo were selected from January 2012 to September 2015 in our hospital. The patients were divided into observation group and control group according to the random number table. The control group was treated with pure western medicine. The observation group was treated with Tongqiao Decoction on the basis of the control group. The blood pressure (SBP, DBP), total effective rate, cholesterol (TC), triglyceride , Low density lipoprotein cholesterol (LDL-C) and other lipid indicators and the incidence of adverse drug reactions during treatment. Results: The compliance rates of SBP and DBP in the observation group were 91.7% and 87.5%, respectively, which were higher than those in the control group (72.9% and 68.8%, P <0.05). The total effective rate of observation group was 89.6%, which was higher than that of control group (64.6%, P <0.05). The levels of TC, TG and LDL-C in the two groups were not significantly different before treatment (P> 0.05). The levels of TC, TG and LDL-C in the observation group after treatment were significantly higher than those before treatment and the control group after treatment (all P <0.05). Conclusion: Tongqiao Dingxue Decoction can treat convulsion of phlegm and blood stasis and vertigo of vertigo. It can strengthen the pressure control effect of western medicine and improve the blood fat, and relieve dizziness more effectively. It is safe and effective.