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本文报道新抗菌素9-甲基链霉戊二酰胺(简称9-MS)在小鼠体内的抗流感病毒作用。 9-MS是从链丝菌S-885的发酵液中分离纯化而得,最终产物为浅黄色的粘性油状物质,系一个独特的戊二酰亚胺类抗菌素,毒性低,对流感病毒A2有很好的预防效果。试验分四组进行,前二组腹腔注射20及10毫克/公斤的9-MS,在5LD_(50)的流感病毒鼻内感染前24,3,1小时及感染后1,3小时以及每天1次连续4天给药。后二组分别注射15毫克/公斤的金刚胺盐酸盐和0.5毫升磷
This article reports the anti-influenza virus effect of the new antibiotic 9-methyl streptomycin glutarimide (referred to as 9-MS) in mice. 9-MS is isolated and purified from the fermentation broth of Streptomyces S-885, the final product is a light yellow viscous oil, a unique glutarimide antibiotic with low toxicity to influenza virus A2 Good preventive effect. The experiment was divided into four groups. The first two groups were injected intraperitoneally with 20 and 10 mg / kg of 9-MS for 24, 3, 1 hours before infection with 5LD_ (50) of influenza virus and 1 hour and 3 hours after infection Times for 4 consecutive days. The latter two groups were injected with 15 mg / kg of amantadine hydrochloride and 0.5 ml of phosphorus, respectively