利血平对豚鼠心房肌的作用

• 作 者: 赵东科 赵更生 明祯
• 机 构: 西安医科大学药理学教研室,西安医科大学药理学教研室,西安医科大学药理学教研室
• 出 处: 西安交通大学学报(医学版)
• 发表日期: 1988年01期
• 关键词: 心房肌 平对 异丙肾上腺素 最大频率 自律性 右移 兴奋性 抑制作用 收缩力 拮抗

利血平能降低豚鼠左心房肌的收缩力,显著抑制肾上腺素诱发自律性的作用;并能延长FRP,而对兴奋性则无影响。此外对豚鼠右房自发频率也有明显抑制作用,使异丙肾上腺素正性频率作用的剂量—效应曲线非平行性右移,并使最大频率反应显著降低;还能显著地对抗CaCl_2的正性频率作用。结果提示利血平对豚鼠心房肌的作用可能与拮抗Ca~(2+)有关。

Reserpine can reduce the contractility of the left atrium of guinea pigs, significantly inhibited the role of adrenaline-induced autonomy; and can extend the FRP, while the excitability had no effect. In addition, the right atrial spontaneous frequency of guinea pigs also significantly inhibited the role of isoproterenol positive frequency of dose-effect curve of non-parallel shift to the right and the maximum frequency response was significantly reduced; but also significantly against the positive frequency of CaCl 2 effect. The results suggest that the effect of reserpine on atrial myocytes in guinea pigs may be related to the antagonism of Ca ~ (2+).