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应用放射免疫分析法检测正常组24例及肠易激综合征(IBS)组26例受检者血浆及乙状结肠粘膜中生长抑素(SS)的含量,旨在探讨IBS患者血浆及乙状结肠粘膜中SS的含量有无变化,以及它在IBS疾病过程中的可能作用和临床意义.结果:IBS组血浆中SS的浓度明显高于正常组(P<0.05);乙状结肠粘膜中SS的含量痛秘型IBS(腹痛、便秘为主)显著高于痛泻型(腹痛、腹泻为主)(P<0.05),痛泻型IBS显著高于正常组(P<0.05).提示SS在IBS的疾病过程中可能起有一定作用,建议在临床实验诊断中验证SS作为IBS诊断标志的可能性.
The contents of somatostatin (SS) in plasma and sigmoid mucosa of 24 patients with normal group and 26 patients with irritable bowel syndrome (IBS) were detected by radioimmunoassay. The aim of this study was to investigate the changes of SS in plasma and sigmoid mucosa of patients with IBS , And its possible role in the pathogenesis of IBS and its clinical significance.Results: The concentration of SS in the plasma of IBS group was significantly higher than that in the normal group (P <0.05) (Mainly abdominal pain and constipation) were significantly higher than those with diarrhea (abdominal pain and diarrhea) (P <0.05), and those with diarrhea and diarrhea were significantly higher than those in normal group (P <0.05), suggesting that SS might be involved in IBS disease Play a role, it is recommended in the clinical laboratory tests to verify the possibility of SS as a diagnostic marker for IBS.