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目的探讨超声联合C型利钠肽检测在新生儿颅内出血诊断中的应用价值。方法选取2015年1月-2016年6月保定市第二中心医院收治的82例颅内出血新生儿为研究对象,对82例患儿进行超声及血浆、脑脊液C型利钠肽检查,然后将检查结果与最终手术结果进行比较,同时比较早产儿与足月儿的检测结果。结果超声联合C型利钠肽的检出率明显高于单用超声与C型利钠肽检查,脑室出血率高于其他部位,早产儿血浆及脑脊液C型利钠肽水平及阳性率也高于足月儿,且所有患儿急性期的血浆及脑脊液C型利钠肽水平即阳性率均高于恢复期,差异均有统计学意义(均P<0.05)。结论超声联合C型利钠肽检测在新生儿颅内出血诊断中的检测价值较高,适用于新生儿颅内出血的诊断,临床应用意义较高。
Objective To investigate the value of ultrasound combined with C-type natriuretic peptide in the diagnosis of neonatal intracranial hemorrhage. Methods Totally 82 neonates with intracranial hemorrhage admitted from the Second Central Hospital of Baoding from January 2015 to June 2016 were enrolled in this study. Totally 82 children were examined with ultrasound and C-type natriuretic peptide in plasma and cerebrospinal fluid. The results were compared with the final surgical results and the results of preterm and full-term infants were compared. Results The detection rate of ultrasound combined with C-type natriuretic peptide was significantly higher than that of ultrasound and C-type natriuretic peptide alone. The rate of ventricular hemorrhage was higher than other sites. The plasma C-type natriuretic peptide and the positive rate in preterm infants were also high In term infants, the positive rates of plasma C-type natriuretic peptide and plasma C-type natriuretic peptide in acute stage of all children were higher than those in recovery stage (all P <0.05). Conclusion Ultrasound combined with C-type natriuretic peptide test in the diagnosis of intracranial hemorrhage in neonatal high detection value, suitable for neonatal intracranial hemorrhage diagnosis, clinical significance.