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目的：探讨急性上呼吸道感染病人单核细胞ADCC效应的变化。方法：利用细胞增殖检测单核／巨噬细胞周ADCC效应方法，测定急性上呼吸道感染病人单核细胞ADCC效应及非特异杀伤效应，并以健康人作为对照组。结果：急性上感伴发热病人单核细胞活化前ADCC（nADCC）效应高于健康对照组（P＜0．05），而活化后ADCC（sADCC）效应无明显变化；上感不伴发热病人nADCC效应低于健康对照组（P＜0．01）；上感病人无论发热与否其单核细胞非特异杀伤效应均高于健康对照组（P＜0．01）。结论：急性上呼吸道感染时发热者与无发热者ADCC效应不一致，单核细胞ApeC效应与非特异性杀伤效应功能状态可不一致。
Objective: To investigate the changes of ADCC in patients with acute upper respiratory tract infection. Methods: Monocyte / macrophage peripheral ADCC effect assay was used to determine the ADCC effect and non-specific killing effect of monocytes in patients with acute upper respiratory tract infection. The healthy volunteers were used as the control group. Results: The activation of ADCC (nADCC) before monocyte activation in patients with acute upper exacerbations was higher than that in healthy controls (P <0.05), while there was no significant change in ADCC (sADCC) after activation. The nADCC (P <0.01). The effect of monocyte-specific non-specific cytotoxicity on the patients with fever was higher than that of the healthy controls (P <0.01). CONCLUSION: The ADCC effects of fever and those without fever are not consistent in acute upper respiratory tract infection. The function of monocyte ApeC and nonspecific killing may not be the same.