论文部分内容阅读
目的 评价低剂量恩丹西酮预防顺铂所致呕吐的效果和不良反应。方法 采用随机自身对照方法 ,将48例接受联合化疗 (舍顺铂 )的患者随机分为A、B两组 ,均接受两个周期相同方案的化疗。A组第 1周期用恩丹西酮 4mg ,第 2周期用恩丹西酮 8mg止吐 ;B组第 1周期用恩丹西酮 8mg ,第 2周期用恩丹西酮 4mg止吐。结果 4mg和 8mg恩丹西酮急性恶心有效率分别为 72 .9% (3 5 48)和 79.2 1% (3 8 48) ,对急性呕吐有效率分别为 87.5 % (4 2 48)和 93 .8% (4 5 48) ,中位呕吐次数分别为 3 .5和 3次。经统计学处理两组差异无显著性。对迟发性呕吐的疗效相似。结论 低剂量恩丹西酮对预防顺铂所致呕吐疗效突出 ,改进的方案用法简便 ,可减少用药少用药量。
Objective To evaluate the efficacy and adverse reactions of low-dose ondansetron in preventing cisplatin-induced vomiting. Methods A randomized self-control study was conducted in 48 patients who received combination chemotherapy (cisplatin). Patients were randomly divided into A and B groups, and both received the same chemotherapy regimen in two cycles. A group of the first cycle with ondansetron 4mg, the second cycle with ondansetron 8mg antiemetic; B group 1 cycle with ondansetron 8mg, the second cycle ondansetron 4mg antiemetic. Results The acute nausea efficacies of ondansetron 4mg and 8mg were 72.9% (3 5 48) and 79.2 1% (388) respectively, respectively, and the rates of acute vomiting were 87.5% (42 48) and 93 respectively. 8% (4548), the median vomiting were 3.5 and 3 times. The statistical difference between the two groups was not significant. The effect of delayed emesis similar. Conclusion Ondansetron low dose on the prevention of cisplatin-induced vomiting, the improved program easy to use, can reduce the medication dose.