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目的研究泛耐药鲍氏不动杆菌(PDRAB)医院感染的危险因素,为有效预防和控制PDRAB医院感染提供参考资料。方法采用病例对照研究方法,对PDRAB感染的相关因素进行分析,确定危险因素。结果 61例PDRAB医院感染患者,感染多发生于入院后1～3周,感染类型以肺部感染为主,占70.5%,其次为创面及血液感染,分别占16.4%、6.6%;单因素分析显示,PDRAB医院感染的危险因素有气管切开(OR=31.0)、呼吸机通气(OR=31.0)、气管插管(OR=16.5)、入住ICU(OR=11.3)、其他插管(OR=2.3)及输氧(OR=2.1);多因素非条件logistic回归分析,进一步得出PDRAB医院感染的独立危险因素为气管切开和呼吸机通气。结论加强重症监护病房的消毒、隔离制度,减少或规避侵入性诊疗操作,是有效预防和控制PDRAB医院感染的关键。
Objective To study the risk factors of nosocomial infection of Pan-drug-resistant Acinetobacter baumannii (PDRAB) and provide references for effective prevention and control of PDRAB nosocomial infections. Methods A case-control study was conducted to analyze the related factors of PDRAB infection and determine the risk factors. Results 61 cases of PDRAB hospital infection, infection occurred in 1 to 3 weeks after admission, the infection type mainly pulmonary infection, accounting for 70.5%, followed by wounds and blood infections, accounting for 16.4%, 6.6%; univariate analysis (OR = 31.0), endotracheal intubation (OR = 16.5), ICU admission (OR = 11.3), other intubation (OR = 2.3) and oxygen (OR = 2.1). Multivariate non-conditional logistic regression analysis further revealed that tracheotomy and ventilator ventilation were the independent risk factors for nosocomial infections in PDRAB. Conclusion To strengthen the system of disinfection and isolation of ICU and to reduce or avoid invasive diagnosis and treatment is the key to effectively prevent and control hospital infection of PDRAB.