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氮氧化物(Nitric Oxide,NO)作为最小的具有多种生物活性的无机分子,正受到越来越多的学者重视。除去可以调节血管平滑肌张力(又称内皮衍生松弛因子,Endotheliumderiued relaking factor,EDRF),影响血小板的粘附与聚积、参与脑及外周神经系统的信息传递之外,NO还是巨噬细胞杀伤肿瘤组织和细菌的重要介质,尤其是在细胞因子导致的组织损伤中,NO的细胞毒性作用引人注
Nitric oxide (NO), as the smallest inorganic molecule with many biological activities, is attracting more and more scholars’ attention. In addition to regulating the vascular smooth muscle tone (also known as endothelial derived relaxation factor, EDRF), affecting platelet adhesion and accumulation, involved in brain and peripheral nervous system information transmission, NO or macrophage killing tumor tissue and Important mediators of bacteria, particularly cytotoxic effects of cytokines, on cytokine-induced tissue damage