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尽管有很多新抗生素出现,但氨基糖苷类抗生素在治疗革兰氏阴性细菌感染中仍起主要作用。本文调查了择期剖腹术病人用丁胺卡那霉素、乙基西索米星和妥布拉霉素后的腹膜渗透作用。共30例(男17例,女13例)择期剖腹术病人参与研究。无病人有腹膜感染的依据。手术当天早上病人随机一次静注了胺卡那霉素、乙基西索米星和妥布拉霉素(分别7.5mg/ks,2.0mg/kg和1.0mg/kg)。手术一进入腹腔就切取少许非炎性腹膜组织,并用无菌盐水冲洗。同时取血标本。所有标本均检测丁胺卡那霉素、乙基西索米星和妥布拉霉素的浓度。
Despite the emergence of many new antibiotics, aminoglycosides continue to play a major role in the treatment of Gram-negative bacterial infections. This article investigates the peritoneal permeation of patients with amiodaron, etidronate and tobramycin following elective cesarean section. A total of 30 patients (17 males and 13 females) were involved in the study. No basis for patients with peritoneal infection. Amikacin, Ethyl Sisomicin and Tobramycin (7.5 mg / ks, 2.0 mg / kg and 1.0 mg / kg, respectively) were randomized on the morning of surgery. As soon as the operation enters the abdominal cavity, a small amount of non-inflammatory peritoneal tissue is removed and rinsed with sterile saline. At the same time take blood samples. All specimens were tested for amikacin, ethyl sisomicin and tobramycin concentration.