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在53名中、老年正常人和66例NIDDM患者中,根据胰岛素分泌指数和红细胞膜胰岛素受体分析的结果表明,正常老年人胰岛素分泌量增多,而末梢组织对胰岛素的敏感性则降低,红细胞膜胰岛素受体数和结合率也降低,此可能系正常老年人糖耐量减退的主要原因之一。中、老年糖尿病患者胰岛素分泌指数、胰岛素受体数以及胰岛素结合率均明显低于正常老年人。对中、老年糖尿病的诊断和治疗作了讨论。治疗重点为饮食调节、适当运动、控制肥胖和高血压。降糖药物以能提高末梢组织利用葡萄糖的磺脲类药物为首选,过程中要防止发生血糖过低症。
According to the results of insulin secretion index and erythrocyte membrane insulin receptor analysis in 53 middle-aged and elderly normal people and 66 cases of NIDDM patients, insulin secretion increased in normal elderly people and the sensitivity of peripheral tissues to insulin decreased. Membrane insulin receptor number and binding rate is also reduced, which may be one of the main causes of impaired glucose tolerance in the elderly. Middle and elderly patients with diabetic insulin secretion index, the number of insulin receptors and insulin binding rates were significantly lower than the normal elderly. The diagnosis and treatment of middle and elderly diabetes were discussed. Treatment focuses on dietary regulation, proper exercise, and control of obesity and high blood pressure. Hypoglycemic drugs to increase the use of peripheral tissues of glucose sulfonylureas preferred, the process should prevent hypoglycemia.