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华盛顿大学医学系的 Matsumoto 等人在男用避孕药的试验中发现大约50%的男性在使用庚酸盐睾酮(TE)后出现精子缺乏症,另外50%的人的精子缺乏则更为严重。为了确定这种精子严重缺乏是否由庚酸盐睾酮所致,作者对6例正常男性作了精子功能研究。6例男性年龄为19～40岁,肌肉注射高剂量的庚酸盐睾酮,其中4例为每星期100mg,2例为300mg,用药期为5～6个月。与此同时,另5例正常男性作为对照组,以注射麻油作为安慰剂。每组在前处理期和处理3个月后均进行一次精液分析和体外精子功能评价(主要用去透明带仓鼠卵穿透试验法,HOPT)。每个受试者在禁欲48
Matsumoto et al. From the Department of Medicine, University of Washington found that about 50% of men in the male contraceptive test found sperm deficiency after using heptate testosterone (TE) and another 50% had more severe sperm deficiency. To determine whether this severe lack of sperm was caused by heptate testosterone, the authors performed sperm function studies on 6 normal males. Six men, aged 19 to 40 years, received intramuscular injections of high-dose heptate testosterone, four of which were 100 mg weekly, two were 300 mg and the duration of medication was 5-6 months. In the meantime, another 5 normal men served as a control group, and sesame oil was injected as a placebo. Semen analysis and in vitro sperm function evaluation were performed in each group (pre-treatment and hamster-egg-penetration test, HOPT) before and 3 months after treatment. Each subject has abstinence 48