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目的:探讨C-反应蛋白(CRP)在动脉粥样硬化形成和发展中的作用以及与冠心病严重程度之间的关系。方法:入选126例患者均进行了冠状动脉造影,其中急性心肌梗死(AMI)组26例,不稳定心绞痛(UAP)组30例,稳定性心绞痛(SAP)组30例,对照组40例。又将冠状动脉造影异常者分为单支血管病变(SVL)组46例和多支血管病变(MVL)组40例。结果:冠心病各亚组血清CRP含量均较对照组升高(P<0.05),其中UAP组和AMI组CRP升高明显(P<0.01);UAP组血清CRP浓度高于SAP组(P<0.01);AMI组血清CRP浓度高于SAP组(P<0.01)和UAP组(P<0.01)。MVL组血清CRP浓度高于SVL组(P<0.01)。结论:CRP在冠心病患者中有不同程度升高,且与冠心病严重程度相关,临床上检测外周血CRP浓度,在诊断冠心病和预测冠心病严重程度方面有较高的临床应用价值。
Objective: To investigate the role of C-reactive protein (CRP) in the formation and development of atherosclerosis and its relationship with the severity of coronary heart disease. Methods: Totally 126 patients underwent coronary angiography. Among them, 26 patients were in acute myocardial infarction (AMI) group, 30 patients were in unstable angina pectoris group (UAP), 30 patients in stable angina pectoris group (SAP) and 40 in control group. In turn, patients with abnormal coronary angiography were divided into single vessel disease (SVL) group of 46 patients and multivessel disease (MVL) group of 40 patients. Results: Serum CRP levels in all subgroups of CHD patients were significantly higher than those in control group (P <0.05). The CRP levels in UAP group and AMI group were significantly higher than those in control group (P <0.01) 0.01). The level of serum CRP in AMI group was higher than that in SAP group (P <0.01) and UAP group (P <0.01). The level of serum CRP in MVL group was higher than that in SVL group (P <0.01). CONCLUSIONS: CRP is elevated in patients with coronary heart disease to some extent, and is related to the severity of coronary heart disease. The level of CRP in peripheral blood is clinically determined. CRP has a high clinical value in diagnosing coronary heart disease and predicting the severity of coronary heart disease.