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目的评价阻塞性睡眠呼吸暂停综合征(OSAS)患者,在正常糖耐量(NGT)时,胰岛β细胞功能和胰岛素抵抗情况。方法选择35例OSAS正常糖耐量(NGT)患者和22例非OSAS非NGT对照者,全部行口服葡萄糖耐量试验,计算早时相胰岛素生成指数△I30/G△30和胰岛素抵抗指数(HOMA-IR)。结果 OSAS正常糖耐量(NGT)患者的△I30/△G30是11.1±5.2;HOMA-IR是5.3±1.2。对照组非OSAS非NGT△I30/△G30是28.3±10.2;HOMA-IR是4.0±3.5。结论 OSAS患者存在胰岛素早期分泌功能缺陷和胰岛素抵抗。
Objective To evaluate the function of islet β cells and insulin resistance during normal glucose tolerance (NGT) in patients with obstructive sleep apnea syndrome (OSAS). Methods Twenty-five patients with OSAS normal glucose tolerance (NGT) and 22 non-OSAS non-NGT controls were enrolled in this study. All patients were given oral glucose tolerance test. The indexes of early phase insulin production, I30 / GΔ30 and HOMA-IR ). Results △ I30 / △ G30 in patients with OSAS normal glucose tolerance (NGT) was 11.1 ± 5.2; HOMA-IR was 5.3 ± 1.2. The non-OSAS non-NGT △ I30 / △ G30 in the control group was 28.3 ± 10.2; the HOMA-IR was 4.0 ± 3.5. Conclusion OSAS patients have early insulin secretion defects and insulin resistance.