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本文应用紫外分光光度法研究了体外三硅酸镁吸附四环素的能力及其与介质 pH 的关系;并应用尿药法研究了三硅酸镁及其在表面活性剂和枸橼酸的存在下对四环素吸收的影响;测定了三种不同处方的四环素混悬剂的相对生物利用度并进行了有关参数的统计比较。实验结果表明:三硅酸镁的吸附能力随介质 pH 的高低而增减。月桂醇硫酸钠和枸橼酸在体外对三硅酸镁有明显的解吸作用,而 Brij-35的解吸作用不明显。四环素与三硅酸镁同服时,前者吸收明显减少(P<0.05)。015g月桂醇硫酸钠与0.3g 三硅酸镁同服使三硅酸镁对四环素的吸附作用有一定程度的抑制,且此抑制作用不随月桂醇硫酸钠剂量继续增大而加强。枸橼酸和 Brij-35在体内均无此作用。三种四环素混悬剂的生物利用度无显著差异(P<0.05)。
In this paper, UV spectrophotometry was used to study the ability of in vitro triclosan to adsorb tetracycline and its relationship with the pH of the medium. Urinary trituration was used to study the effect of trisilicate on the adsorption of tetracycline in the presence of surfactant and citric acid Tetracycline absorption; Determination of the relative bioavailability of tetracycline suspension of three different prescriptions and the statistical comparison of the parameters. The experimental results show that the adsorption capacity of magnesium trisilicate increases or decreases with the medium pH. Sodium lauryl sulfate and citric acid have obvious desorption effect on magnesium trisilicate in vitro, while the desorption effect of Brij-35 is not obvious. Tetracycline and trisilicate with the same service, the former significantly reduced the absorption (P <0.05). 015g sodium lauryl sulfate and 0.3g trisilicate with magnesium silicate tetracycline adsorption to a certain extent, and this inhibition does not with the dose of sodium lauryl sulfate continue to increase and strengthened. Citric acid and Brij-35 have no effect in the body. The bioavailability of the three tetracycline suspensions showed no significant difference (P <0.05).