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目的观察卡培他滨联合奥沙利铂组成的XELOX方案治疗晚期大肠癌的近期疗效与安全性。方法采用XELOX方案治疗晚期大肠癌62例。卡培他滨2000mg/m2,d1～14,分早晚口服;奥沙利铂130mg/m2,d1,静点。每21天为1周期,至少2周期。结果近期疗效CR1例,PR26例,SD20例,PD15例,有效率43.5%。初治组有效率55.6%,显著高于复治组的26.9%(P<0.05)。毒副反应主要为可耐受的骨髓抑制、恶心呕吐、外周神经毒性。结论XELOX方案治疗晚期大肠癌疗效较好,毒副反应轻,是晚期大肠癌,特别是初治者的有效治疗方案。
Objective To observe the short-term efficacy and safety of capecitabine combined with oxaliplatin in the treatment of advanced colorectal cancer. Methods XELOX regimen in the treatment of advanced colorectal cancer in 62 cases. Capecitabine 2000mg / m2, d1 ~ 14, points morning and evening oral; oxaliplatin 130mg / m2, d1, static point. Every 21 days for a period of at least 2 cycles. The results of the recent CR1 efficacy, PR26 cases, SD20 cases, PD15 cases, the effective rate of 43.5%. The effective rate of the primary treatment group was 55.6%, significantly higher than that of the retreatment group (26.9%, P <0.05). Toxic side effects are mainly tolerable myelosuppression, nausea and vomiting, peripheral neurotoxicity. Conclusion XELOX regimen is effective in treating advanced colorectal cancer with mild toxic side effects, which is an effective treatment for advanced colorectal cancer, especially for those who are newly diagnosed.